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http://purl.uniprot.org/citations/10512681http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10512681http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10512681http://www.w3.org/2000/01/rdf-schema#comment"TIAM1 is a guanine nucleotide exchange factor that was identified in a screen for genes that increase the invasiveness of T lymphoma cell lines (Habets et al., 1994, Cell 77(4): 537-549). We have identified a gene, T-cell lymphoma invasion and metastasis 2 (HGMW-approved symbol TIAM2), with significant identity to the carboxyl-terminal region of the TIAM1 and mapped it to 6q25. TIAM2 is expressed as an approximately 3.3-kb transcript in cerebrum and as an approximately 4.4-kb transcript in the cerebellum and testis. The approximately 4. 4-kb message encodes a longer form of the approximately 3.3-kb mRNA predicted protein, and both contain homology to the Dbl-homologous region (70%) and Pleckstrin-homologous (54%) regions of TIAM1. We have purified TIAM2 and shown it to have GDP-GTP exchange activity. In situ hybridizations demonstrate TIAM2 expression in the E13.5 telencephalon of mouse embryos and in the cerebral cortex, hippocampus, and ependyma of adult mouse brains."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.org/dc/terms/identifier"doi:10.1006/geno.1999.5936"xsd:string
http://purl.uniprot.org/citations/10512681http://purl.org/dc/terms/identifier"doi:10.1006/geno.1999.5936"xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Kim E."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Kim E."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Duhl D.M."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Duhl D.M."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Leng S."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Leng S."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Martin K.A."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Martin K.A."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Chiu C.-Y."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Chiu C.-Y."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Gorman S."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/author"Gorman S."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/name"Genomics"xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/name"Genomics"xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/pages"66-73"xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/pages"66-73"xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/title"Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1."xsd:string
http://purl.uniprot.org/citations/10512681http://purl.uniprot.org/core/title"Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1."xsd:string