| http://purl.uniprot.org/citations/10512748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10512748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10512748 | http://www.w3.org/2000/01/rdf-schema#comment | "The MUC3 gene encodes a large, glycosylated mucin produced by intestinal epithelial cells to form a protective barrier against the external environment. Recently published cDNA sequences for the carboxyl-terminal region of MUC3 polypeptide indicated that rodent Muc3 possesses two epidermal growth factor (EGF)-like domains, and putative transmembrane and cytoplasmic domains, whereas the sequence of human MUC3 predicted termination after the first EGF-like domain. Here we describe the complete genomic sequence encompassing the carboxyl terminal region of human MUC3, revealing the boundaries of 11 exons. RT-PCR and cDNA library cloning experiments indicate that the gene is alternatively spliced, yielding a major membrane-bound form as well as multiple soluble forms. Thus, this work indicates that both membrane-bound and soluble MUC3 mucin proteins are produced by alternative splicing of a single gene. A potentially important polymorphism involving a Tyr residue with a proposed role in signalling is described as well."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.1466"xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.1466"xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Aubert J.-P."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Aubert J.-P."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Hicks J.W."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Hicks J.W."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Pratt W.S."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Pratt W.S."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Gum J.R. Jr."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Gum J.R. Jr."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Swallow D.M."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Swallow D.M."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Crawley S.C."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/author | "Crawley S.C."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/pages | "728-736"xsd:string |
| http://purl.uniprot.org/citations/10512748 | http://purl.uniprot.org/core/pages | "728-736"xsd:string |