| http://purl.uniprot.org/citations/10519414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10519414 | http://www.w3.org/2000/01/rdf-schema#comment | "Uridine phosphorylase (UPase) plays an important role in the activation of 5-fluorouracil and in the regulation of tissue and plasma concentration of uridine, a potential biochemical modulator of 5-fluorouracil therapy. UPase expression is affected by the c-H-ras oncogene and various cytokines through unknown mechanisms. To understand its expression and regulation, we cloned the murine UPase gene, defined its genomic organization, determined its 5'- and 3'-end flanking sequences, and evaluated the promoter activity. The UPase gene contains nine exons and eight introns, spanning a total of approximately 18.0 kb. Its promoter lacks canonical TATA and CCAAT boxes, although a CAATAAAAA TATA-like box is seen from -41 to -49. Furthermore, IFN regulatory factor 1, c/v-Myb, and p53 binding sites are present in the promoter region, indicating that UPase expression may be directly regulated by cytokines and oncogene products. The 1.2-kb flanking fragment showed promoter activity driving the expression of the luciferase gene in various mammalian cells. A TGGGG repeat sequence is seen in the 3'-end flanking region. This element is considered to be a potential recombination consensus hot spot that may contribute to the encoding of different UPase isoforms present in different tissues, both normal and neoplastic."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/author | "Handschumacher R.E."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/author | "Cao D."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/author | "Bray-Ward P."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/author | "Nimmakayalu M.A."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/author | "Pizzorno G."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/pages | "4997-5001"xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/title | "Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene."xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/10519414 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10519414 |
| http://purl.uniprot.org/citations/10519414 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10519414 |
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