| http://purl.uniprot.org/citations/10519552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10519552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10519552 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial preproteins are imported by a multisubunit translocase of the outer membrane (TOM), including receptor proteins and a general import pore. The central receptor Tom22 binds preproteins through both its cytosolic domain and its intermembrane space domain and is stably associated with the channel protein Tom40 (refs 11-13). Here we report the unexpected observation that a yeast strain can survive without Tom22, although it is strongly reduced in growth and the import of mitochondrial proteins. Tom22 is a multifunctional protein that is required for the higher-level organization of the TOM machinery. In the absence of Tom22, the translocase dissociates into core complexes, representing the basic import units, but lacks a tight control of channel gating. The single membrane anchor of Tom22 is required for a stable interaction between the core complexes, whereas its cytosolic domain serves as docking point for the peripheral receptors Tom20 and Tom70. Thus a preprotein translocase can combine receptor functions with distinct organizing roles in a multidomain protein."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.org/dc/terms/identifier | "doi:10.1038/46802"xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.org/dc/terms/identifier | "doi:10.1038/46802"xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Hill K."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Hill K."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Maarse A.C."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Maarse A.C."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Wagner R."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Wagner R."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Guiard B."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Guiard B."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Meisinger C."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Meisinger C."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Pfanner N."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Pfanner N."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Ryan M.T."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Ryan M.T."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Meijer M."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Meijer M."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Hoenlinger A."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Hoenlinger A."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Moczko M."xsd:string |
| http://purl.uniprot.org/citations/10519552 | http://purl.uniprot.org/core/author | "Moczko M."xsd:string |