RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/10520994http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10520994http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10520994http://www.w3.org/2000/01/rdf-schema#comment"Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin 1 (Plex 1) and neuropilin-1 (NP-1), form a stable complex. Plex 1 alone does not bind semaphorin-3A (Sema3A), but the NP-1/Plex 1 complex has a higher affinity for Sema3A than does NP-1 alone. While Sema3A binding to NP-1 does not alter nonneuronal cell morphology, Sema3A interaction with NP-1/Plex 1 complexes induces adherent cells to round up. Expression of a dominant-negative Plex 1 in sensory neurons blocks Sema3A-induced growth cone collapse. Sema3A treatment leads to the redistribution of growth cone NP-1 and plexin into clusters. Thus, physiologic Sema3A receptors consist of NP-1/plexin complexes."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)80062-8"xsd:string
http://purl.uniprot.org/citations/10520994http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)80062-8"xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Fournier A."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Fournier A."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Murakami Y."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Murakami Y."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Takahashi T."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Takahashi T."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Nakamura F."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Nakamura F."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Wang L.-H."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Wang L.-H."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Fujisawa H."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Fujisawa H."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Strittmatter S.M."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Strittmatter S.M."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Kalb R.G."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/author"Kalb R.G."xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/10520994http://purl.uniprot.org/core/name"Cell"xsd:string