| http://purl.uniprot.org/citations/10521354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10521354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10521354 | http://www.w3.org/2000/01/rdf-schema#comment | "Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Here, the isolation of the gene for an enzyme that can hydrolyze the bond between this protein and DNA is described. Enzyme-defective mutants of yeast are hypersensitive to treatments that increase the amount of covalent complexes, indicative of enzyme involvement in repair. The gene is conserved in eukaryotes and identifies a family of enzymes that has not been previously recognized. The presence of this gene in humans may have implications for the effectiveness of topoisomerase I poisons, such as the camptothecins, in chemotherapy."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.286.5439.552"xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.286.5439.552"xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/author | "Nash H.A."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/author | "Nash H.A."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/author | "Pouliot J.J."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/author | "Pouliot J.J."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/author | "Robertson C.A."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/author | "Robertson C.A."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/author | "Yao K.C."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/author | "Yao K.C."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/pages | "552-555"xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/pages | "552-555"xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/title | "Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/title | "Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes."xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/10521354 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10521354 |
| http://purl.uniprot.org/citations/10521354 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10521354 |