| http://purl.uniprot.org/citations/10523291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10523291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10523291 | http://www.w3.org/2000/01/rdf-schema#comment | "The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2-2A(pro)) has been solved to 1.95 A resolution. The structure has an unusual, although chymotrypsin-related, fold comprising a unique four-stranded beta sheet as the N-terminal domain and a six-stranded beta barrel as the C-terminal domain. A tightly bound zinc ion, essential for the stability of HRV2-2A(pro), is tetrahedrally coordinated by three cysteine sulfurs and one histidine nitrogen. The active site consists of a catalytic triad formed by His18, Asp35 and Cys106. Asp35 is additionally involved in an extensive hydrogen-bonding network. Modelling studies reveal a substrate-induced fit that explains the specificity of the subsites S4, S2, S1 and S1'. The structure of HRV2-2A(pro) suggests the mechanism of the cis cleavage and its release from the polyprotein."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.20.5463"xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.20.5463"xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Cherney M.M."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Cherney M.M."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "James M.N."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "James M.N."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Petersen J.F."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Petersen J.F."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Skern T."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Skern T."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Kuechler E."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Kuechler E."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Liebig H.D."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/author | "Liebig H.D."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/pages | "5463-5475"xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/pages | "5463-5475"xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/title | "The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis."xsd:string |
| http://purl.uniprot.org/citations/10523291 | http://purl.uniprot.org/core/title | "The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis."xsd:string |