| http://purl.uniprot.org/citations/10523301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10523301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10523301 | http://www.w3.org/2000/01/rdf-schema#comment | "In Rat-1 fibroblasts epidermal growth factor (EGF), but not platelet-derived growth factor (PDGF) stimulates the activity of the c-Jun N-terminal kinase (JNK). Moreover, PDGF induced suppression of EGF-mediated JNK activation, apparently through protein kinase C (PKC) activation. Further analysis revealed that PKD was specifically activated by PDGF but not EGF in Rat-1 cells. In SF126 glioblastoma cells, however, EGF and PDGF synergistically activated JNK, while neither PDGF nor EGF stimulated PKD activity. In this cell line, overexpression of PKD blocked EGF- and PDGF-induced JNK activation. Mutational analysis further revealed that the EGFR mutant (T654/669E) was incapable of activating JNK and provided evidence that PKD-mediated dual phosphorylation of these critical threonine residues leads to suppression of EGF-induced JNK activation. Our results establish a novel crosstalk mechanism which allows signal integration and definition in cells with many different RTKs."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.20.5567"xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.20.5567"xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/author | "Ullrich A."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/author | "Ullrich A."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/author | "Choidas A."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/author | "Choidas A."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/author | "Bagowski C.P."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/author | "Bagowski C.P."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/author | "Stein-Gerlach M."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/author | "Stein-Gerlach M."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/pages | "5567-5576"xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/pages | "5567-5576"xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/title | "Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/title | "Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor."xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10523301 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10523301 |
| http://purl.uniprot.org/citations/10523301 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10523301 |