| http://purl.uniprot.org/citations/10524629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10524629 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms controlling the commitment of haematopoietic progenitors to the B-lymphoid lineage are poorly understood. The observations that mice deficient in E2A and EBF lack B-lineage cells have implicated these two transcription factors in the commitment process. Moreover, the expression of genes encoding components of the rearrangement machinery (RAG1, RAG2, TdT) or pre-B-cell receptor (lambda5, VpreB, Igalpha, Igbeta) has been considered to indicate B-lineage commitment. All these genes including E2A and EBF are expressed in pro-B cells lacking the transcription factor Pax5. Here we show that cloned Pax5-deficient pro-B cells transferred into RAG2-deficient mice provide long-term reconstitution of the thymus and give rise to mature T cells expressing alpha/beta-T-cell receptors. The bone marrow of these mice contains a population of cells of Pax5-/-origin with the same phenotype as the donor pro-B cells. When transferred into secondary recipients, these pro-B cells again home to the bone marrow and reconstitute the thymus. Hence, B-lineage commitment is determined neither by immunoglobulin DJ rearrangement nor by the expression of E2A, EBF, lambda5, VpreB, Igalpha and Igbeta. Instead, our data implicate Pax5 in the control of B-lineage commitment."xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.org/dc/terms/identifier | "doi:10.1038/44164"xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/author | "Melchers F."xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/author | "Nutt S.L."xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/author | "Rolink A.G."xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/pages | "603-606"xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/title | "Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors."xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://purl.uniprot.org/core/volume | "401"xsd:string |
| http://purl.uniprot.org/citations/10524629 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10524629 |
| http://purl.uniprot.org/citations/10524629 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10524629 |
| http://purl.uniprot.org/uniprot/Q02548#attribution-919C849ABB0009CD4E67A2708D2DC682 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10524629 |