| http://purl.uniprot.org/citations/10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10531040 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammals, growth of the fetal heart is regulated by proliferation of cardiac muscle cells. At later stages of pre-natal life, this proliferation diminishes profoundly [1] [2] and the dramatic expansion in heart size during the transition to adulthood is due exclusively to hypertrophy of individual cardiomyocytes [3] [4] [5]. Cardiomyocyte hypertrophy also contributes to the pathology of most post-natal heart disease [6] [7] [8] [9] [10]. Within this context, numerous signal transduction pathways have been implicated as the link between the effector(s) and altered cardiac gene expression [11] [12] [13] [14] [15] [16]. A common pathway has yet to be discovered, however. Here, we found that the activity of the stress-activated kinase p38 was enhanced in both types of cardiomyocyte hypertrophy. We also found that a target of the activated p38 kinase is the cardiac transcription factor MEF2. Transgenic mice expressing a dominant-negative form of MEF2C displayed attenuated post-natal growth of the myocardium. These results provide the first evidence for a single pathway regulating both normal and pathologic cardiomyocyte hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(00)80027-5"xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/author | "Kothary R."xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/author | "Megeney L.A."xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/author | "Kolodziejczyk S.M."xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/author | "Balazsi K."xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/author | "DeRepentigny Y."xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/pages | "1203-1206"xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/title | "MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium."xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/10531040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10531040 |
| http://purl.uniprot.org/citations/10531040 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10531040 |
| http://purl.uniprot.org/uniprot/Q8CFN5#attribution-52CF4CEB92FF11C0A84638640460A6CC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10531040 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDK0-mappedCitation-10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531040 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDQ1-mappedCitation-10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531040 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDT0-mappedCitation-10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531040 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE18-mappedCitation-10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531040 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE38-mappedCitation-10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531040 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFX2-mappedCitation-10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531040 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK3-mappedCitation-10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531040 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGL3-mappedCitation-10531040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531040 |