| http://purl.uniprot.org/citations/10531320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10531320 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1beta (IL-1beta) and prostaglandin E(2) (PGE(2)), frequently co-participants in inflammatory states, are two well recognized inhibitors of glucose-induced insulin secretion. Previous reports have concluded that the inhibitory effects of these two autacoids on pancreatic beta cell function are not related because indomethacin, a potent prostaglandin synthesis inhibitor, does not prevent IL-1beta effects. However, indomethacin is not a specific cyclooxygenase inhibitor, and its other pharmacologic effects are likely to inhibit insulin secretion independently. Since we recently observed that IL-1beta induces cyclooxygenase-2 (COX-2) gene expression and PGE(2) synthesis in islet beta cells, we have reassessed the possibility that PGE(2) mediates IL-1beta effects on beta function. By using two cell lines (HIT-T15 and betaHC13) as well as Wistar rat isolated pancreatic islets, we examined the ability of two COX-2-specific antagonists, NS-398 and SC-236, to prevent IL-1beta inhibition of insulin secretion. Both drugs prevented IL-1beta from inducing PGE(2) synthesis and inhibiting insulin secretion; adding back exogenous PGE(2) re-established inhibition of insulin secretion in the presence of IL-1beta. We also found that EP3, the PGE(2) receptor subtype whose post-receptor effect is to decrease adenylyl cyclase activity and, thereby, insulin secretion, is the dominant mRNA subtype expressed. We conclude that endogenous PGE(2) mediates the inhibitory effects of exogenous IL-1beta on beta cell function."xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.44.31245"xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/author | "Robertson R.P."xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/author | "Poitout V."xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/author | "Gleason C.E."xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/author | "Tran P.O."xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/pages | "31245-31248"xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/title | "Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta."xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10531320 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10531320 |
| http://purl.uniprot.org/citations/10531320 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10531320 |
| http://purl.uniprot.org/uniprot/P34980#attribution-9D9F6B27C5AF86B7074403751362A627 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10531320 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JSK4-mappedCitation-10531320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531320 |
| http://purl.uniprot.org/uniprot/#_G3V7D9-mappedCitation-10531320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531320 |
| http://purl.uniprot.org/uniprot/#_P34980-mappedCitation-10531320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10531320 |
| http://purl.uniprot.org/uniprot/A0A0G2JSK4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10531320 |
| http://purl.uniprot.org/uniprot/G3V7D9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10531320 |
| http://purl.uniprot.org/uniprot/P34980 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10531320 |