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| http://purl.uniprot.org/citations/10534616 | http://www.w3.org/2000/01/rdf-schema#comment | "The most obvious phenotype of Ft/+ mice is a syndactyly of fore limbs characterised by a fusion of the tips of digits 1 to 4. The tempospatial expression of genes involved in limb development revealed that patterning of Ft/+ limb buds is not affected by the mutation. However, an upregulation of Bmp4 in the anterior-distal region of the limb bud at d12.0 of embryonic development is accompanied by a loss of Fgf8 expression in the distal part of the AER. Downstream target genes of Bmp action such as Msx1 and 2 are upregulated. This induction of the signalling cascade indicates ectopic expression of functional Bmp4. Nevertheless, analysis of physical parameters of bones from adult mice revealed a reduction of the bone mass of the autopod. The data suggest a negative effect of Bmp4 on Fgf8 expression and a positive influence on the induction of bone elements."xsd:string |
| http://purl.uniprot.org/citations/10534616 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0925-4773(99)00186-0"xsd:string |
| http://purl.uniprot.org/citations/10534616 | http://purl.uniprot.org/core/author | "Ruther U."xsd:string |
| http://purl.uniprot.org/citations/10534616 | http://purl.uniprot.org/core/author | "Heymer J."xsd:string |
| http://purl.uniprot.org/citations/10534616 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10534616 | http://purl.uniprot.org/core/name | "Mech Dev"xsd:string |
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| http://purl.uniprot.org/citations/10534616 | http://purl.uniprot.org/core/title | "Syndactyly of Ft/+ mice correlates with an imbalance in bmp4 and fgf8 expression."xsd:string |
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