| http://purl.uniprot.org/citations/10535925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10535925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10535925 | http://www.w3.org/2000/01/rdf-schema#comment | "Posttranslational modifications such as ubiquitination and phosphorylation play an important role in the regulation of cellular protein function. Homeodomain-interacting protein kinase 2 (HIPK2) is a member of the recently identified family of nuclear protein kinases that act as corepressors for homeodomain transcription factors. Here, we show that HIPK2 is regulated by a ubiquitin-like protein, SUMO-1. We demonstrate that HIPK2 localizes to nuclear speckles (dots) by means of a speckle-retention signal. This speckle-retention signal contains a domain that interacts with a mouse ubiquitin-like protein conjugating (E2) enzyme, mUBC9. In cultured cells, HIPK2 is covalently modified by SUMO-1, and the SUMO-1 modification of HIPK2 correlates with its localization to nuclear speckles (dots). Thus, our results provide firm evidence that the nuclear protein kinase HIPK2 can be covalently modified by SUMO-1, which directs its localization to nuclear speckles (dots)."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.22.12350"xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.22.12350"xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/author | "Choi C.Y."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/author | "Choi C.Y."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/pages | "12350-12355"xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/pages | "12350-12355"xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/title | "Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/title | "Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1."xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10535925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10535925 |
| http://purl.uniprot.org/citations/10535925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10535925 |
| http://purl.uniprot.org/citations/10535925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10535925 |
| http://purl.uniprot.org/citations/10535925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10535925 |