| http://purl.uniprot.org/citations/10535969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10535969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10535969 | http://www.w3.org/2000/01/rdf-schema#comment | "The signal transduction and activation of RNA (STAR) family of RNA-binding proteins, whose members are evolutionarily conserved from yeast to humans, are important for a number of developmental decisions. For example, in the mouse, quaking proteins (QKI-5, QKI-6, and QKI-7) are essential for embryogenesis and myelination, whereas a closely related protein in Caenorhabditis elegans, germline defective-1 (GLD-1), is necessary for germ-line development. Recently, GLD-1 was found to be a translational repressor that acts through regulatory elements, called TGEs (for tra-2 and GLI elements), present in the 3' untranslated region of the sex-determining gene tra-2. This gene promotes female development, and repression of tra-2 translation by TGEs is necessary for the male cell fates. The finding that GLD-1 inhibits tra-2 translation raises the possibility that other STAR family members act by a similar mechanism to control gene activity. Here we demonstrate, both in vitro and in vivo, that QKI-6 functions in the same manner as GLD-1 and can specifically bind to TGEs to repress translation of reporter constructs containing TGEs. In addition, expression of QKI-6 in C. elegans wild-type hermaphrodites or in hermaphrodites that are partially masculinized by a loss-of-function mutation in the sex-determining gene tra-3 results in masculinization of somatic tissues, consistent with QKI-6 repressing the activity of tra-2. These results strongly suggest that QKI-6 may control gene activity by operating through TGEs to regulate translation. In addition, our data support the hypothesis that other STAR family members may also be TGE-dependent translational regulators."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.22.12605"xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.22.12605"xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Jan E."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Jan E."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Saccomanno L."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Saccomanno L."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Artzt K."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Artzt K."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Goodwin E.B."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Goodwin E.B."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Loushin C."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Loushin C."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Punkay E."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/author | "Punkay E."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/pages | "12605-12610"xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/pages | "12605-12610"xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/title | "The STAR protein QKI-6 is a translational repressor."xsd:string |
| http://purl.uniprot.org/citations/10535969 | http://purl.uniprot.org/core/title | "The STAR protein QKI-6 is a translational repressor."xsd:string |