| http://purl.uniprot.org/citations/10545116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10545116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10545116 | http://www.w3.org/2000/01/rdf-schema#comment | "NRIF (neurotrophin receptor interacting factor) is a ubiquitously expressed zinc finger protein of the Krüppel family which interacts with the neurotrophin receptor p75(NTR). The interaction was first detected in yeast and then biochemically confirmed using recombinant GST-NRIF fusions and p75(NTR) expressed by eukaryotic cells. Transgenic mice carrying a deletion in the exon encoding the p75(NTR)-binding domain of NRIF display a phenotype which is strongly dependent upon genetic background. While at the F(2 )generation there is only limited (20%) embryonic lethality, in a congenic BL6 strain nrif(-/-) mice cannot survive beyond E12, but are viable and healthy to adulthood in the Sv129 background. The involvement of NRIF in p75(NTR)/NGF-mediated developmental cell death was examined in the mouse embryonic neural retina. Disruption of the nrif gene leads to a reduction in cell death which is quantitatively indistinguishable from that observed in p75(NTR)(-/-) and ngf(-/-) mice. These results indicate that NRIF is an intracellular p75(NTR)-binding protein transducing cell death signals during development."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.21.6050"xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.21.6050"xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Frade J.M."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Frade J.M."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Carter B.D."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Carter B.D."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Barde Y.A."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Barde Y.A."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Benzel I."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Benzel I."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Casademunt E."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Casademunt E."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Dechant G."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/author | "Dechant G."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/pages | "6050-6061"xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/pages | "6050-6061"xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/title | "The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death."xsd:string |
| http://purl.uniprot.org/citations/10545116 | http://purl.uniprot.org/core/title | "The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death."xsd:string |