| http://purl.uniprot.org/citations/10545246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10545246 | http://www.w3.org/2000/01/rdf-schema#comment | "To isolate the genes involved in mouse primordial germ cell (PGC) development, we carried out subtraction cDNA cloning between PGC-derived embryonic germ (EG) cells and inner cell mass-derived embryonic stem cells. Among the genes preferentially expressed in EG cells, we found a gene encoding a receptor tyrosine kinase ErbB3. By in situ hybridization and immunohistochemical staining, the expression of ErbB3 as well as that of ErbB2, a coreceptor for ErbB3, was detected in PGCs in genital ridges at 12.5 dpc (days postcoitum). The expression was, however, downregulated at 14.5 dpc when the PGCs underwent growth cessation. Neuregulin-beta, a ligand for ErbB2 and ErbB3, was also expressed in genital ridges. In addition, a recombinant Neuregulin-beta enhanced the number of PGCs in 12.5-dpc embryos in culture. Taken together, these observations suggest that ErbB signaling controls the growth or survival of PGCs in genital ridges."xsd:string |
| http://purl.uniprot.org/citations/10545246 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.1999.9482"xsd:string |
| http://purl.uniprot.org/citations/10545246 | http://purl.uniprot.org/core/author | "Obinata M."xsd:string |
| http://purl.uniprot.org/citations/10545246 | http://purl.uniprot.org/core/author | "Matsui Y."xsd:string |
| http://purl.uniprot.org/citations/10545246 | http://purl.uniprot.org/core/author | "Toyoda-Ohno H."xsd:string |
| http://purl.uniprot.org/citations/10545246 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10545246 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/10545246 | http://purl.uniprot.org/core/pages | "399-406"xsd:string |
| http://purl.uniprot.org/citations/10545246 | http://purl.uniprot.org/core/title | "Members of the ErbB receptor tyrosine kinases are involved in germ cell development in fetal mouse gonads."xsd:string |
| http://purl.uniprot.org/citations/10545246 | http://purl.uniprot.org/core/volume | "215"xsd:string |
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