| http://purl.uniprot.org/citations/10545451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10545451 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified two classical extragenic suppressors, spp41 and spp42, of the temperature sensitive (ts) allele prp4-73. The prp4(+) gene of Schizosaccharomyces pombe encodes a protein kinase. Mutations in both suppressor genes suppress the growth and the pre-mRNA splicing defect of prp4-73(ts) at the restrictive temperature (36 degrees ). spp41 and spp42 are synthetically lethal with each other in the presence of prp4-73(ts), indicating a functional relationship between spp41 and spp42. The suppressor genes were mapped on the left arm of chromosome I proximal to the his6 gene. Based on our mapping data we isolated spp42 by screening PCR fragments for functional complementation of the prp4-73(ts) mutant at the restrictive temperature. spp42 encodes a large protein (p275), which is the homologue of Prp8p. This protein has been shown in budding yeast and mammalian cells to be a bona fide pre-mRNA splicing factor. Taken together with other recent genetic and biochemical data, our results suggest that Prp4 kinase plays an important role in the formation of catalytic spliceosomes."xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/153.3.1183"xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/author | "Schmidt H."xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/author | "Kaufer N.F."xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/author | "Richert K."xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/author | "Drakas R.A."xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/pages | "1183-1191"xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/title | "spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p."xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/10545451 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10545451 |
| http://purl.uniprot.org/citations/10545451 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10545451 |
| http://purl.uniprot.org/uniprot/#_Q07538-mappedCitation-10545451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10545451 |
| http://purl.uniprot.org/uniprot/Q07538 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10545451 |