| http://purl.uniprot.org/citations/10545458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10545458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10545458 | http://www.w3.org/2000/01/rdf-schema#comment | "Formation of crossovers between homologous chromosomes during Caenorhabditis elegans meiosis requires the him-14 gene. Loss of him-14 function severely reduces crossing over, resulting in lack of chiasmata between homologs and consequent missegregation. Cytological analysis showing that homologs are paired and aligned in him-14 pachytene nuclei, together with temperature-shift experiments showing that him-14 functions during the pachytene stage, indicate that him-14 is not needed to establish pairing or synapsis and likely has a more direct role in crossover formation. him-14 encodes a germline-specific member of the MutS family of DNA mismatch repair (MMR) proteins. him-14 has no apparent role in MMR, but like its Saccharomyces cerevisiae ortholog MSH4, has a specialized role in promoting crossing over during meiosis. Despite this conservation, worms and yeast differ significantly in their reliance on this pathway: whereas worms use this pathway to generate most, if not all, crossovers, yeast still form 30-50% of their normal number of crossovers when this pathway is absent. This differential reliance may reflect differential stability of crossover-competent recombination intermediates, or alternatively, the presence of two different pathways for crossover formation in yeast, only one of which predominates during nematode meiosis. We discuss a model in which HIM-14 promotes crossing over by interfering with Holliday junction branch migration."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/153.3.1271"xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/153.3.1271"xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "Zalevsky J."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "Zalevsky J."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "Villeneuve A.M."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "Villeneuve A.M."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "Duffy J.B."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "Duffy J.B."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "Kemphues K.J."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "Kemphues K.J."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "MacQueen A.J."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/author | "MacQueen A.J."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/pages | "1271-1283"xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/pages | "1271-1283"xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/title | "Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/title | "Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast."xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/10545458 | http://purl.uniprot.org/core/volume | "153"xsd:string |