| http://purl.uniprot.org/citations/10545507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10545507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10545507 | http://www.w3.org/2000/01/rdf-schema#comment | "Duchenne muscular dystrophy is a fatal muscle disease that is often associated with cognitive impairment. Accordingly, dystrophin is found at the muscle sarcolemma and at postsynaptic sites in neurons. In muscle, dystrophin forms part of a membrane-spanning complex, the dystrophin-associated protein complex (DPC). Whereas the composition of the DPC in muscle is well documented, the existence of a similar complex in brain remains largely unknown. To determine the composition of DPC-like complexes in brain, we have examined the molecular associations and distribution of the dystrobrevins, a widely expressed family of dystrophin-associated proteins, some of which are components of the muscle DPC. beta-Dystrobrevin is found in neurons and is highly enriched in postsynaptic densities (PSDs). Furthermore, beta-dystrobrevin forms a specific complex with dystrophin and syntrophin. By contrast, alpha-dystrobrevin-1 is found in perivascular astrocytes and Bergmann glia, and is not PSD-enriched. alpha-Dystrobrevin-1 is associated with Dp71, utrophin, and syntrophin. In the brains of mice that lack dystrophin and Dp71, the dystrobrevin-syntrophin complexes are still formed, whereas in dystrophin-deficient muscle, the assembly of the DPC is disrupted. Thus, despite the similarity in primary sequence, alpha- and beta-dystrobrevin are differentially distributed in the brain where they form separate DPC-like complexes."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.147.3.645"xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.147.3.645"xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/author | "Benson M.A."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/author | "Benson M.A."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/author | "Hawkes R."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/author | "Hawkes R."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/author | "Beesley P.W."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/author | "Beesley P.W."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/author | "Blake D.J."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/author | "Blake D.J."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/pages | "645-658"xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/pages | "645-658"xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/title | "Different dystrophin-like complexes are expressed in neurons and glia."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/title | "Different dystrophin-like complexes are expressed in neurons and glia."xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/10545507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10545507 |
| http://purl.uniprot.org/citations/10545507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10545507 |