| http://purl.uniprot.org/citations/10549281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10549281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10549281 | http://www.w3.org/2000/01/rdf-schema#comment | "Using a functional screen in Xenopus embryos, we identified a novel function for the HMG box protein XSox17 beta. Ectopic expression of XSox17 beta ventralizes embryos by inhibiting the Wnt pathway downstream of beta-catenin but upstream of the Wnt-responsive gene Siamois. XSox17 beta also represses transactivation of a TCF/LEF-dependent reporter construct by Wnt and beta-catenin. In animal cap experiments, it both activates transcription of endodermal genes and represses beta-catenin-stimulated expression of dorsal genes. The inhibition activity of XSox17 beta maps to a region C-terminal to the HMG box; this region of XSox17 beta physically interacts with the Armadillo repeats of beta-catenin. Two additional Sox proteins, XSox17 alpha and XSox3, likewise bind to beta-catenin and inhibit its TCF-mediated signaling activity. These results reveal an unexpected mechanism by which Sox proteins can modulate Wnt signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)80200-2"xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)80200-2"xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Varmus H.E."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Varmus H.E."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Zorn A.M."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Zorn A.M."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Barish G.D."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Barish G.D."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Lavender P."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Lavender P."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Williams B.O."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Williams B.O."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Klymkowsky M.W."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/author | "Klymkowsky M.W."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/pages | "487-498"xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/pages | "487-498"xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/title | "Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/10549281 | http://purl.uniprot.org/core/title | "Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin."xsd:string |