| http://purl.uniprot.org/citations/10549282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10549282 | http://www.w3.org/2000/01/rdf-schema#comment | "TGF-beta treatment of cells induces a variety of physiologic responses, including growth inhibition, differentiation, and induction of apoptosis. TGF-beta induces phosphorylation and nuclear translocation of Smad3. We describe here the association of Smad3 with the nuclear protooncogene protein Ski in response to the activation of TGF-beta signaling. Association with Ski represses transcriptional activation by Smad3, and overexpression of Ski renders cells resistant to the growth-inhibitory effects of TGF-beta. The transcriptional repression as well as the growth resistance to TGF-beta by overexpression of Ski can be overcome by overexpression of Smad3. These results demonstrate that Ski is a novel component of the TGF-beta signaling pathway and shed light on the mechanism of action of the Ski oncoprotein."xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)80201-4"xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/author | "Lane W.S."xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/author | "Lodish H.F."xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/author | "Weinberg R.A."xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/author | "Eaton E.N."xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/pages | "499-509"xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/title | "Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling."xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/10549282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10549282 |
| http://purl.uniprot.org/citations/10549282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10549282 |
| http://purl.uniprot.org/uniprot/#_Q13485-mappedCitation-10549282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10549282 |
| http://purl.uniprot.org/uniprot/#_Q15796-mappedCitation-10549282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10549282 |
| http://purl.uniprot.org/uniprot/#_O75376-mappedCitation-10549282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10549282 |
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| http://purl.uniprot.org/uniprot/#_P12757-mappedCitation-10549282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10549282 |
| http://purl.uniprot.org/uniprot/#_P84022-mappedCitation-10549282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10549282 |
| http://purl.uniprot.org/uniprot/#_Q9Y618-mappedCitation-10549282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10549282 |
| http://purl.uniprot.org/uniprot/Q15796 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10549282 |
| http://purl.uniprot.org/uniprot/O75376 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10549282 |