| http://purl.uniprot.org/citations/10549856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10549856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10549856 | http://www.w3.org/2000/01/rdf-schema#comment | "A new antibiotic, korormicin, isolated from a marine bacterium Pseudoalteromonas sp. F-420, was found to strongly inhibit the respiratory chain-linked Na+-translocating NADH-quinone reductase (NQR) from the marine Vibrio alginolyticus. Similar to 2-n-heptyl-4-hydroxyquinoline N-oxide (HQNO), korormicin specifically inhibited the Na+-dependent reaction in the NQR complex that is directly coupled to the extrusion of Na+ from the cells. Both korormicin and HQNO acted as purely noncompetitive inhibitors with regard to Q-1, and the inhibitor constants were estimated to be 82 pM and 0.3 microM, respectively. Mutual exclusiveness of korormicin and HQNO was analyzed by kinetic methods, which indicated that a part of the binding site of korormicin and HQNO overlapped, preventing a simultaneous binding of the two inhibitors to the NQR complex. The site of Ag+ inhibition was the initial reaction of the NQR complex catalyzed by Nqr6 subunit. The time courses of Ag+ inhibition and the release of FAD indicate that the Ag+-denatured Nqr6 subunit gradually releases FAD."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.org/dc/terms/identifier | "doi:10.1248/bpb.22.1064"xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.org/dc/terms/identifier | "doi:10.1248/bpb.22.1064"xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Hayashi M."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Hayashi M."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Mochida K."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Mochida K."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Nakayama Y."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Nakayama Y."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Yoshikawa K."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Yoshikawa K."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Unemoto T."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/author | "Unemoto T."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/name | "Biol. Pharm. Bull."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/name | "Biol. Pharm. Bull."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/pages | "1064-1067"xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/pages | "1064-1067"xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/title | "Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+ toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/title | "Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+ toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus."xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/10549856 | http://purl.uniprot.org/core/volume | "22"xsd:string |