| http://purl.uniprot.org/citations/10556215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10556215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10556215 | http://www.w3.org/2000/01/rdf-schema#comment | "The NUP98 gene is involved in 3 distinct chromosomal rearrangements, t(7;11)(p15;p15), t(2;11)(q31;p15), and inv(11)(p15q22); all of these NUP98 rearrangements have been identified in the malignant cells of patients with therapy-related acute myelogenous leukemia or myelodysplastic syndrome (t-AML/MDS). Here we report the cloning and characterization of a t(11;20)(p15;q11) translocation from patients with t-MDS. The breakpoint on chromosome 11p15 targets the NUP98 gene and results in the separation of the N-terminal FXFG repeats from the RNA-binding domain located in the C-terminus. The breakpoint on chromosome 20q11 occurs within the gene encoding human DNA topoisomerase I (TOP1). As a result, a chimeric mRNA encoding the NUP98 FXFG repeats fused to the body of DNA topoisomerase I is produced. These results indicate that NUP98 is a recurrent target in therapy-related malignancies, and that TOP1 is a previously unrecognized target for chromosomal translocations."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/author | "Aplan P.D."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/author | "Aplan P.D."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/author | "Felix C.A."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/author | "Felix C.A."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/author | "Ahuja H.G."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/author | "Ahuja H.G."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/pages | "3258-3261"xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/pages | "3258-3261"xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/title | "The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/title | "The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion."xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/10556215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10556215 |
| http://purl.uniprot.org/citations/10556215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10556215 |
| http://purl.uniprot.org/citations/10556215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10556215 |
| http://purl.uniprot.org/citations/10556215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10556215 |
| http://purl.uniprot.org/uniprot/P11387 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10556215 |
| http://purl.uniprot.org/uniprot/P52948 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10556215 |