| http://purl.uniprot.org/citations/10557097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10557097 | http://www.w3.org/2000/01/rdf-schema#comment | "Complex chromosomal rearrangements (deletions, inversions, translocations) are a hallmark of human tumour cells. Yet, the generation of animal models for gross chromosomal abnormalities still presents a formidable challenge. Here, we describe a versatile procedure for chromosomal engineering that was used to generate an ES cell line with a megabase deletion encompassing the tumour suppressor gene neurofibromatosis-1 (Nf-1) on mouse chromosome 11, which is often deleted in tumours of neural crest origin. Homologous recombination into sites flanking Nf-1 was used to introduce artificial sequences (triple-helix, loxP, vector backbone) that can be employed for in vitro recovery of intervening sequences or the generation of in vivo deletions. This strategy may be developed into a scheme by which large chromosomal regions with precisely defined end points may be excised from mammalian cells and reintroduced after suitable in vitro modification."xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203021"xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/author | "Schupp I."xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/author | "Boehm T."xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/author | "Lichter P."xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/author | "Kutsche K."xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/author | "Mincheva A."xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/author | "Schlake T."xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/pages | "6078-6082"xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/title | "Predetermined chromosomal deletion encompassing the Nf-1 gene."xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/10557097 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10557097 |
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