| http://purl.uniprot.org/citations/10557321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10557321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10557321 | http://www.w3.org/2000/01/rdf-schema#comment | "A role for glycoprotein (GP)V in platelet function has been proposed on the basis of observations that GP V is the major thrombin substrate on intact platelets cleaved during thrombin-induced platelet aggregation, and that GP V promotes GP Ib-IX surface expression in heterologous cells. We tested the hypotheses that GP V is involved in thrombin-induced platelet activation, in GP Ib-IX expression, and in other platelet responses by generating GP V null mice. Contrary to expectations, GP V -/-platelets were normal in size and expressed normal amounts of GP Ib-IX that was functional in von Willebrand factor binding, explaining why defects in GP V have not been observed in Bernard-Soulier syndrome, a bleeding disorder caused by a lack of functional GP Ib-IX-V. Moreover, in vitro analysis demonstrated that GP V -/-platelets were hyperresponsive to thrombin, resulting in increased fibrinogen binding and an increased aggregation response. Consistent with these findings, GP V -/-mice had a shorter bleeding time. These data support a role for GP V as a negative modulator of platelet activation. Furthermore, they suggest a new mechanism by which thrombin enhances platelet responsiveness independent of activation of the classical G-protein-coupled thrombin receptors."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.23.13336"xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.23.13336"xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Ramakrishnan V."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Ramakrishnan V."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Phillips D.R."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Phillips D.R."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "DeGuzman F."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "DeGuzman F."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Deshpande U."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Deshpande U."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "DuBridge R.B."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "DuBridge R.B."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Ministri-Madrid K."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Ministri-Madrid K."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Reeves P.S."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/author | "Reeves P.S."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/pages | "13336-13341"xsd:string |
| http://purl.uniprot.org/citations/10557321 | http://purl.uniprot.org/core/pages | "13336-13341"xsd:string |