| http://purl.uniprot.org/citations/10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10559189 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional repression by sequence-specific DNA binding factors is mediated by the recruitment of a corepressor complex to the promoter region. The NK-3 homeodomain protein is a transcriptional repressor that recruits the nuclear protein kinase, homeodomain interacting protein kinase 2 (HIPK2). Here we show that HIPK2 is a component of a corepressor complex containing Groucho and a histone deacetylase complex. Groucho, like HIPK2, acts as a corepressor for NK-3 and binds to NK-3 and HIPK2. Moreover, HIPK2 appears to regulate the corepressor activity of Groucho. Transcriptional repression by NK-3 and Groucho is relieved by the histone deacetylase inhibitor trichostatin A, and both NK-3 and Groucho directly interact with the histone deacetylase HDAC1 that is associated with mSin3A in vivo. Recruitment of the histone deacetylase complex by NK-3 decreases the acetylated histones that are associated with the target gene promoter. These results indicate that NK-3 represses transcription by recruiting a complex containing Groucho and a histone deacetylase complex that leads to histone modification on chromatin and suggest that HIPK2 may play a regulatory role in the corepressor complex formation."xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.47.33194"xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/author | "Kwon H.J."xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/author | "Choi C.Y."xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/pages | "33194-33197"xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/title | "The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription."xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10559189 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10559189 |
| http://purl.uniprot.org/citations/10559189 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10559189 |
| http://purl.uniprot.org/uniprot/#_Q13547-mappedCitation-10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10559189 |
| http://purl.uniprot.org/uniprot/#_Q04724-mappedCitation-10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10559189 |
| http://purl.uniprot.org/uniprot/#_Q04725-mappedCitation-10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10559189 |
| http://purl.uniprot.org/uniprot/#_Q04726-mappedCitation-10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10559189 |
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| http://purl.uniprot.org/uniprot/#_P36402-mappedCitation-10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10559189 |
| http://purl.uniprot.org/uniprot/#_Q9HCS4-mappedCitation-10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10559189 |
| http://purl.uniprot.org/uniprot/#_Q9UJU2-mappedCitation-10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10559189 |
| http://purl.uniprot.org/uniprot/#_Q9NQB0-mappedCitation-10559189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10559189 |
| http://purl.uniprot.org/uniprot/Q04724 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10559189 |
| http://purl.uniprot.org/uniprot/Q04726 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10559189 |