| http://purl.uniprot.org/citations/10559333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10559333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10559333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10559333 | http://www.w3.org/2000/01/rdf-schema#comment | "Faba bean necrotic yellows virus (FBNYV) belongs to the nanoviruses, plant viruses whose genome consists of multiple circular single-stranded DNA components. Eleven distinct DNAs, 5 of which encode different replication initiator (Rep) proteins, have been identified in two FBNYV isolates. Origin-specific DNA cleavage and nucleotidyl transfer activities were shown for Rep1 and Rep2 proteins in vitro, and their essential tyrosine residues that catalyze these reactions were identified by site-directed mutagenesis. In addition, we showed that Rep1 and Rep2 proteins hydrolyze ATP, and by changing the key lysine residue in the proteins' nucleoside triphosphate binding sites, demonstrated that this ATPase activity is essential for multiplication of virus DNA in vivo. Each of the five FBNYV Rep proteins initiated replication of the DNA molecule by which it was encoded, but only Rep2 was able to initiate replication of all the six other genome components. Furthermore, of the five rep components, only the Rep2-encoding DNA was always detected in 55 FBNYV samples from eight countries. These data provide experimental evidence for a master replication protein encoded by a multicomponent single-stranded DNA virus."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.73.12.10173-10182.1999"xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.73.12.10173-10182.1999"xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Gronenborn B."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Gronenborn B."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Gronenborn B."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Katul L."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Katul L."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Katul L."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Timchenko T."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Timchenko T."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Vetten H.J."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Vetten H.J."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Vetten H.J."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "David C."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "David C."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "David C."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "de Kouchkovsky F."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "de Kouchkovsky F."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "de Kouchkovsky F."xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/author | "Timchenko T"xsd:string |
| http://purl.uniprot.org/citations/10559333 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |