| http://purl.uniprot.org/citations/10567243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10567243 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian S100A1 protein can activate the invertebrate myosin-associated giant protein kinase twitchin in a Ca(2+)-dependent manner by more than 1000-fold in vitro; however, no mammalian S100-dependent protein kinases are known. In an attempt to identify novel mammalian Ca(2+)/S100A1-regulated protein kinases, brain extracts were subjected to combined Ca(2+)-dependent affinity chromatography with S100A1 and an ATP analogue. This resulted in the purification to near-homogeneity of the four major synapsin isoforms Ia, Ib, IIa and IIb. All four synapsins were specifically affinity-labelled with the ATP analogue 5'-p-fluorosulphonylbenzoyladenosine. S100A1 bound to immobilized synapsin IIa in BIAcore experiments in a Ca(2+)-dependent and Zn(2+)-enhanced manner with submicromolar affinity; this interaction could be competed for with synthetic peptides of the proposed S100A1-binding sites of synapsin. Double-labelling confocal immunofluorescence microscopy demonstrated that synapsins and S100A1 are both present in the soma and neurites of PC12 cells, indicating their potential to interact in neurons in vivo."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3440577"xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/author | "Czernik A.J."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/author | "Heierhorst J."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/author | "Kemp B.E."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/author | "Mann R.J."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/author | "Mitchelhill K.I."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/author | "Tiganis T."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/pages | "577-583"xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/title | "Synapsins as major neuronal Ca2+/S100A1-interacting proteins."xsd:string |
| http://purl.uniprot.org/citations/10567243 | http://purl.uniprot.org/core/volume | "344"xsd:string |
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