| http://purl.uniprot.org/citations/10570155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10570155 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of integrins to mediate cell attachment to extracellular matrices and to blood proteins is regulated from inside the cell. Increased ligand-binding activity of integrins is critical for platelet aggregation upon blood clotting and for leukocyte extravasation to inflamed tissues. Decreased adhesion is thought to promote tumor cell invasion. R-Ras, a small intracellular GTPase, regulates the binding of integrins to their ligands outside the cell. Here we show that the Eph receptor tyrosine kinase, EphB2, can control integrin activity through R-Ras. Cells in which EphB2 is activated become poorly adherent to substrates coated with integrin ligands, and a tyrosine residue in the R-Ras effector domain is phosphorylated. The R-Ras phosphorylation and loss of cell adhesion are causally related, because forced expression of an R-Ras variant resistant to phosphorylation at the critical site made cells unresponsive to the anti-adhesive effect of EphB2. This is an unusual regulatory pathway among the small GTPases. Reduced adhesiveness induced through the Eph/R-Ras pathway may explain the repulsive effect of the Eph receptors in axonal pathfinding and may facilitate tumor cell invasion and angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.24.13813"xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/author | "Ruoslahti E."xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/author | "Zou J.X."xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/author | "Pasquale E.B."xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/author | "Zisch A.H."xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/author | "Kalo M.S."xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/pages | "13813-13818"xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/title | "An Eph receptor regulates integrin activity through R-Ras."xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10570155 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10570155 |
| http://purl.uniprot.org/citations/10570155 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10570155 |
| http://purl.uniprot.org/uniprot/#_P10301-mappedCitation-10570155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10570155 |
| http://purl.uniprot.org/uniprot/P10301 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10570155 |