| http://purl.uniprot.org/citations/10570958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10570958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10570958 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt proteins influence many aspects of embryonic development, and their activity is regulated by several secreted antagonists, including the Xenopus Dickkopf-1 (xDkk-1) protein. xDkk-1 inhibits Wnt activities in Xenopus embryos and may play a role in induction of head structures. Here, we characterize a family of human Dkk-related genes composed of Dkk-1, Dkk-2, Dkk-3, and Dkk-4, together with a unique Dkk-3 related protein termed Soggy (Sgy). hDkks 1-4 contain two distinct cysteine-rich domains in which the positions of 10 cysteine residues are highly conserved between family members. Sgy is a novel secreted protein related to Dkk-3 but which lacks the cysteine-rich domains. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. Furthermore, secreted hDkk-2 and hDkk-4 undergo proteolytic processing which results in cleavage of the second cysteine-rich domain from the full-length protein. Members of the human Dkk-related family differ not only in their structures and expression patterns, but also in their abilities to inhibit Wnt signaling. hDkk-1 and hDkk-4, but not hDkk-2, hDkk-3 or Sgy, suppress Wnt-induced secondary axis induction in Xenopus embryos. hDkk-1 and hDkk-4 do not block axis induction triggered either by Xenopus Dishevelled (Xdsh) or Xenopus Frizzled-8 (Xfz8), both of which function to transduce signals from Wnt ligands. Thus, hDkks 1 and 4 may inhibit Wnt activity by a mechanism upstream of Frizzled. Our findings highlight the structural and functional heterogeneity of human Dkk-related proteins."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(99)00365-0"xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(99)00365-0"xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Jiang C."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Jiang C."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Chang B."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Chang B."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Robison K."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Robison K."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Duong T."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Duong T."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Gearing D.P."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Gearing D.P."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Chickering T.W."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Chickering T.W."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Brown D.E."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Brown D.E."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Sokol S.Y."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Sokol S.Y."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Sharp J.D."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Sharp J.D."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Amaravadi L."xsd:string |
| http://purl.uniprot.org/citations/10570958 | http://purl.uniprot.org/core/author | "Amaravadi L."xsd:string |