| http://purl.uniprot.org/citations/10574923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10574923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10574923 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular responses to viral infection are signaled by double-stranded (ds) RNA, which is not found in substantial amounts in uninfected cells. Although cellular dsRNA-binding proteins have been described, their characterization is incomplete. We show that dsRNA-binding proteins are prominent autoantigens. Sera from B6 and B10.S mice with pristane-induced lupus and human autoimmune sera immunoprecipitated a novel set of 130-, 110-, 90-, 80-, and 45-kDa proteins. The proteins were all major cellular poly(IC)-binding factors. N-terminal amino acid sequences of p110 and p90 were identical and matched nuclear factor (NF) 90 and M phase phosphoprotein 4. p45 and p90 were identified as the NF45.NF90 complex, which binds the interleukin-2 promoter as well as certain highly structured viral RNAs. NF90.NF45 and M phase phosphoprotein 4 belong to a large group of proteins with conserved dsRNA-binding motifs. Besides binding dsRNA, NF90.NF45, p110, and p130 had single-stranded and dsDNA binding activity. Some sera contained autoantibodies whose binding was inhibited by poly(IC) but not single-stranded DNA or vice versa, suggesting that the DNA- and RNA-binding sites are different. These autoantibodies will be useful probes of the function of dsRNA-binding proteins. Their interaction with dsRNA, an immunological adjuvant, also could promote autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.49.34598"xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.49.34598"xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Shaw M."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Shaw M."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Kao P.N."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Kao P.N."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Satoh M."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Satoh M."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Okano T."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Okano T."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Reeves W.H."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Reeves W.H."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Richards H.B."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Richards H.B."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Shaheen V.M."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/author | "Shaheen V.M."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10574923 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |