| http://purl.uniprot.org/citations/10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10580127 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycosylation of glycoproteins and glycolipids is one of many molecular changes that accompany malignant transformation. GlcNAc-branched N-glycans and terminal Lewis antigen sequences have been observed to increase in some cancers, and to correlate with poor prognosis. Herein, we review evidence that beta1, 6GlcNAc-branching of N-glycans contributes directly to cancer progression, and we consider possible functions for the glycans. Mgat5 encodes N-acetylglucosaminyltransferase V (GlcNAc-TV), the Golgi enzyme required in the biosynthesis of beta1,6GlcNAc-branched N-glycans. Mgat5 expression is regulated by RAS-RAF-MAPK, a signaling pathway commonly activated in tumor cells. Ectopic expression of GlcNAc-TV in epithelial cells results in morphological transformation and tumor growth in mice, and over expression in carcinoma cells has been shown to induce metastatic spread. Ectopic expression of GlcNAc-TIII, an enzyme that competes with GlcNAc-TV for acceptor, suppresses metastasis in B16 melanoma cells. Furthermore, breast cancer progression and metastasis induced by a viral oncogene expressed in transgenic mice is markedly suppressed in a GlcNAc-TV-deficient background. Mgat5 gene expression and beta1, 6GlcNAc-branching of N-glycans are associated with cell motility, a required phenotype of malignant cells."xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0304-4165(99)00167-1"xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://purl.uniprot.org/core/author | "Dennis J.W."xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://purl.uniprot.org/core/author | "Warren C.E."xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://purl.uniprot.org/core/author | "Granovsky M."xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10580127 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://purl.uniprot.org/core/pages | "21-34"xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://purl.uniprot.org/core/title | "Glycoprotein glycosylation and cancer progression."xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://purl.uniprot.org/core/volume | "1473"xsd:string |
| http://purl.uniprot.org/citations/10580127 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10580127 |
| http://purl.uniprot.org/citations/10580127 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10580127 |
| http://purl.uniprot.org/uniprot/#_Q10470-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/#_J3JS24-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/#_Q059T5-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/#_P27808-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/#_Q544F0-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/#_Q8CIC9-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/#_Q5RKT9-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/#_Q8R4G5-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/#_Q8R4G6-mappedCitation-10580127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/Q5RKT9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/Q10470 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10580127 |
| http://purl.uniprot.org/uniprot/Q8CIC9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10580127 |