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http://purl.uniprot.org/citations/10586026http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10586026http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10586026http://www.w3.org/2000/01/rdf-schema#comment"To explore the phylogenetic history of the murine paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) types, we isolated PIR homologues from a rat splenocyte cDNA library. The rat (ra) PIR-A and raPIR-B cDNA sequences predict transmembrane proteins with six highly conserved extracellular Ig-like domains and distinctive membrane proximal, transmembrane, and cytoplasmic regions. The raPIR-B cytoplasmic region contains prototypic inhibitory motifs, whereas raPIR-A features a charged transmembrane region and a short cytoplasmic tail. Southern blot analysis predicts the presence of multiple Pira genes and a single Pirb gene in the rat genome. Although raPIR-A and raPIR-B are coordinately expressed by myeloid cells, analysis of mRNA detected unpaired expression of raPIR-A by B cells and raPIR-B by NK cells. Collectively, these findings indicate that the structural hallmarks of the Pir gene family are conserved in rats and mice, yet suggest divergence of PIR regulatory elements during rodent speciation."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/author"Cooper M.D."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/author"Cooper M.D."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/author"Dennis G. Jr."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/author"Dennis G. Jr."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/author"Kubagawa H."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/author"Kubagawa H."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/author"Stephan R.P."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/author"Stephan R.P."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/name"J. Immunol."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/name"J. Immunol."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/pages"6371-6377"xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/pages"6371-6377"xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/title"Characterization of paired Ig-like receptors in rats."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/title"Characterization of paired Ig-like receptors in rats."xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/volume"163"xsd:string
http://purl.uniprot.org/citations/10586026http://purl.uniprot.org/core/volume"163"xsd:string
http://purl.uniprot.org/citations/10586026http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10586026
http://purl.uniprot.org/citations/10586026http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10586026
http://purl.uniprot.org/citations/10586026http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10586026
http://purl.uniprot.org/citations/10586026http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10586026