| http://purl.uniprot.org/citations/10587356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10587356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10587356 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel T cell-specific adaptor protein, RIBP, was identified based on its ability to bind Rlk/Txk in a yeast two-hybrid screen of a mouse T cell lymphoma library. RIBP was also found to interact with a related member of the Tec family of tyrosine kinases, Itk. Expression of RIBP is restricted to T and natural killer cells and is upregulated substantially after T cell activation. RIBP-disrupted knockout mice displayed apparently normal T cell development. However, proliferation of RIBP-deficient T cells in response to T cell receptor (TCR)-mediated activation was significantly impaired. Furthermore, these activated T cells were defective in the production of interleukin (IL)-2 and interferon gamma, but not IL-4. These data suggest that RIBP plays an important role in TCR-mediated signal transduction pathways and that its binding to Itk and Rlk/Txk may regulate T cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.190.11.1657"xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.190.11.1657"xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Love P.E."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Love P.E."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Rajagopal K."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Rajagopal K."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Sommers C.L."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Sommers C.L."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Bluestone J.A."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Bluestone J.A."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Korthauer U."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Korthauer U."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Mitchell E.O."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Mitchell E.O."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Sperling A.I."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Sperling A.I."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Decker D.C."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/author | "Decker D.C."xsd:string |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10587356 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |