| http://purl.uniprot.org/citations/10587642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10587642 | http://www.w3.org/2000/01/rdf-schema#comment | "SMAD proteins are phosphorylated by transforming growth factor-beta (TGF-beta) receptors and translocate to the nucleus, where they control transcription. Here we investigate the fate of activated Smad2. We show that receptor-mediated activation leads to multi-ubiquitination and subsequent degradation of Smad2 by the proteasome. Ubiquitination of Smad2 is a consequence of its accumulation in the nucleus. If degradation is averted, the phosphorylated Smad2 remains in the nucleus in an active state. By targeting Smad2 for destruction, TGF-beta ensures the irreversible termination of its own signalling function."xsd:string |
| http://purl.uniprot.org/citations/10587642 | http://purl.org/dc/terms/identifier | "doi:10.1038/70258"xsd:string |
| http://purl.uniprot.org/citations/10587642 | http://purl.uniprot.org/core/author | "Lo R.S."xsd:string |
| http://purl.uniprot.org/citations/10587642 | http://purl.uniprot.org/core/author | "Massague J."xsd:string |
| http://purl.uniprot.org/citations/10587642 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10587642 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10587642 | http://purl.uniprot.org/core/pages | "472-478"xsd:string |
| http://purl.uniprot.org/citations/10587642 | http://purl.uniprot.org/core/title | "Ubiquitin-dependent degradation of TGF-beta-activated smad2."xsd:string |
| http://purl.uniprot.org/citations/10587642 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/10587642 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10587642 |
| http://purl.uniprot.org/citations/10587642 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10587642 |
| http://purl.uniprot.org/uniprot/#_Q13485-mappedCitation-10587642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10587642 |
| http://purl.uniprot.org/uniprot/#_P51668-mappedCitation-10587642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10587642 |
| http://purl.uniprot.org/uniprot/#_Q15796-mappedCitation-10587642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10587642 |
| http://purl.uniprot.org/uniprot/#_P84022-mappedCitation-10587642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10587642 |
| http://purl.uniprot.org/uniprot/#_P61077-mappedCitation-10587642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10587642 |
| http://purl.uniprot.org/uniprot/Q15796 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10587642 |
| http://purl.uniprot.org/uniprot/Q13485 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10587642 |
| http://purl.uniprot.org/uniprot/P61077 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10587642 |
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| http://purl.uniprot.org/uniprot/P84022 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10587642 |