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http://purl.uniprot.org/citations/10587644http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10587644http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10587644http://www.w3.org/2000/01/rdf-schema#comment"The human cullin protein CUL-2 functions in a ubiquitin-ligase complex with the von Hippel-Lindau (VHL) tumour suppressor protein. Here we show that, in Caenorhabditis elegans, cul-2 is expressed in proliferating cells and is required at two distinct points in the cell cycle, the G1-to-S-phase transition and mitosis. cul-2 mutant germ cells undergo a G1-phase arrest that correlates with accumulation of CKI-1, a member of the CIP/KIP family of cyclin-dependent-kinase inhibitors. In cul-2 mutant embryos, mitotic chromosomes are unable to condense, leading to unequal DNA segregation, chromosome bridging and the formation of multiple nuclei."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.org/dc/terms/identifier"doi:10.1038/70272"xsd:string
http://purl.uniprot.org/citations/10587644http://purl.org/dc/terms/identifier"doi:10.1038/70272"xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Feng H."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Feng H."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Gu S."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Gu S."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Zhou L."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Zhou L."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Zhong W."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Zhong W."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Kipreos E.T."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Kipreos E.T."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Punkosdy G."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Punkosdy G."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Seabolt E.K."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/author"Seabolt E.K."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/name"Nat. Cell Biol."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/name"Nat. Cell Biol."xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/pages"486-492"xsd:string
http://purl.uniprot.org/citations/10587644http://purl.uniprot.org/core/pages"486-492"xsd:string