| http://purl.uniprot.org/citations/10597293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10597293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10597293 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently we found that NEDD8, a ubiquitin-like protein, was linked covalently to human cullin-4A (abbreviated Cul-4A) by a new ubiquitin-related pathway that is analogous to but distinct from the ligating system for SUMO1, another ubiquitin-like protein. However, it remained unknown whether the other five members of the family of human cullin/Cdc53 proteins are modified by NEDD8. Here we report that all Hs-Cul family proteins, such as Cul-1, Cul-2, Cul-3, Cul-4B, and Cul-5, in addition to Cul-4A, were modified by covalent attachment of NEDD8 in rabbit reticulocyte lysates. Moreover, by comprehensive Northern-blot analyses, we examined multiple tissue distributions of the messages for all Cul-family proteins, NEDD8, and the NEDD8-ligating system consisting of APP-BP1/hUba3, and hUbc12, which function as E1- and E2-like enzymes, respectively. The expressions of Cul-1, Cul-2, and Cul-3 resembled each other and were apparently correlated to those of NEDD8 and the NEDD8-ligating system in various human cells and tissues. However, the mRNA levels of Cul-4A, Cul-4B, and Cul-5 differed considerably from each other as well as from other Cul-family proteins. The enhanced expression of all Cul-family proteins except Cul-5 was observed in a variety of tumor cell lines."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203093"xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203093"xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Kato S."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Kato S."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Hori T."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Hori T."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Miyamoto C."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Miyamoto C."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Osaka F."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Osaka F."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Okabayashi K."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Okabayashi K."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Shimbara N."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/author | "Shimbara N."xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10597293 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |