| http://purl.uniprot.org/citations/10600756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10600756 | http://www.w3.org/2000/01/rdf-schema#comment | "In this report, we demonstrate that a fetal mouse skin-derived dendritic cell line produces nitric oxide (NO) in response to the endotoxin [lipopolysaccharide (LPS)] and to cytokines [tumor necrosis factor-alpha (TNF-alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF)]. Expression of the inducible isoform of NO synthase (iNOS) was confirmed by immunofluorescence with an antibody against iNOS. The tyrosine kinase inhibitor genistein decreased LPS- and GM-CSF-induced nitrite (NO(-2)) production. The effect of LPS and cytokines on NO(-2) production was inhibited by the Janus kinase 2 (JAK2) inhibitor tyrphostin B42. The p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB-203580 also reduced the NO(-2) production evoked by LPS, TNF-alpha, or GM-CSF, but it was not as effective as tyrphostin B42. Inhibition of MAPK kinase with PD-098059 also slightly reduced the effect of TNF-alpha or GM-CSF on NO(-2) production. Immunocytochemistry studies revealed that the transcription factor nuclear factor-kappaB was translocated from the cytoplasm into the nuclei of fetal skin-derived dendritic cells (FSDC) stimulated with LPS, and this translocation was inhibited by tyrphostin B42. Our results show that JAK2 plays a major role in the induction of iNOS in FSDC."xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.1999.277.6.c1050"xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/author | "Duarte C.B."xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/author | "Carvalho A.P."xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/author | "Lopes M.C."xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/author | "Cruz M.T."xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/author | "Goncalo M."xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/name | "Am J Physiol"xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/pages | "C1050-7"xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/title | "Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/10600756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10600756 |
| http://purl.uniprot.org/citations/10600756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10600756 |
| http://purl.uniprot.org/uniprot/Q62120#attribution-4E1DF4D8F7CF39A047ACBC53619CBA35 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10600756 |
| http://purl.uniprot.org/uniprot/#_A0A494BBB9-mappedCitation-10600756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10600756 |
| http://purl.uniprot.org/uniprot/#_Q62120-mappedCitation-10600756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10600756 |
| http://purl.uniprot.org/uniprot/Q62120 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10600756 |
| http://purl.uniprot.org/uniprot/A0A494BBB9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10600756 |