| http://purl.uniprot.org/citations/10601346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10601346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10601346 | http://www.w3.org/2000/01/rdf-schema#comment | "ZO-1, ZO-2, and ZO-3, which contain three PDZ domains (PDZ1 to -3), are concentrated at tight junctions (TJs) in epithelial cells. TJ strands are mainly composed of two distinct types of four-transmembrane proteins, occludin, and claudins, between which occludin was reported to directly bind to ZO-1/ZO-2/ZO-3. However, in occludin-deficient intestinal epithelial cells, ZO-1/ZO-2/ZO-3 were still recruited to TJs. We then examined the possible interactions between ZO-1/ZO-2/ZO-3 and claudins. ZO-1, ZO-2, and ZO-3 bound to the COOH-terminal YV sequence of claudin-1 to -8 through their PDZ1 domains in vitro. Then, claudin-1 or -2 was transfected into L fibroblasts, which express ZO-1 but not ZO-2 or ZO-3. Claudin-1 and -2 were concentrated at cell-cell borders in an elaborate network pattern, to which endogenous ZO-1 was recruited. When ZO-2 or ZO-3 were further transfected, both were recruited to the claudin-based networks together with endogenous ZO-1. Detailed analyses showed that ZO-2 and ZO-3 are recruited to the claudin-based networks through PDZ2 (ZO-2 or ZO-3)/PDZ2 (endogenous ZO-1) and PDZ1 (ZO-2 or ZO-3)/COOH-terminal YV (claudins) interactions. In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.147.6.1351"xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.147.6.1351"xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Kubota K."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Kubota K."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Itoh M."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Itoh M."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Tsukita S."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Tsukita S."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Morita K."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Morita K."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Saitou M."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Saitou M."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Furuse M."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/author | "Furuse M."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/pages | "1351-1363"xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/pages | "1351-1363"xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/title | "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."xsd:string |
| http://purl.uniprot.org/citations/10601346 | http://purl.uniprot.org/core/title | "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."xsd:string |