| http://purl.uniprot.org/citations/10602018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10602018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10602018 | http://www.w3.org/2000/01/rdf-schema#comment | "TEA (T early alpha) is a genetic element located upstream of the TCR-Jalpha cluster. Thymocytes from mice carrying a targeted deletion of TEA do not rearrange their TCRalpha locus on a window spanning the first nine Jalpha segments. This led us to the hypothesis of TEA having a "rearrangement focusing" activity on the 5' side of the TCR-Jalpha region. We analyzed DNAseI and "phylogenetic" footprints within the TEA promoter in an attempt to identify trans-acting factors that could account for its regulatory function on DNA accessibility. One of these footprints corresponded to a putative DNA-binding site for an orphan nuclear receptor of the ROR / RZR family. The RORgammaT cDNA clone was isolated from a thymus library using a probe corresponding to the DNA-binding domain of RORgamma / TOR. RORgammaT is a thymus-specific isoform of RORgamma, expressed almost exclusively in immature double-positive thymocytes. RORgammaT binds, to the TEA promoter in vitro. Lastly, the expression of RORgammaT is stimulated in two situations that mimic activation through the pre-TCR and in which the thymocytes have their TCR-alpha locus in an "open", yet unrearranged DNA configuration. We propose that the expression of RORgammaT may be part of the pre-TCR activation cascade leading to the maturation of alpha / beta T cells and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1521-4141(199912)29:12<4072::aid-immu4072>3.0.co;2-e"xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1521-4141(199912)29:12<4072::aid-immu4072>3.0.co;2-e"xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/author | "Villey I."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/author | "Villey I."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/author | "De Chasseval R."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/author | "De Chasseval R."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/author | "De Villartay J.-P."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/author | "De Villartay J.-P."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/pages | "4072-4080"xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/pages | "4072-4080"xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/title | "RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORg/TOR, is up-regulated by signaling through the pre-T cell receptor (TCR) and binds to the TEA promoter."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/title | "RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORg/TOR, is up-regulated by signaling through the pre-T cell receptor (TCR) and binds to the TEA promoter."xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/10602018 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10602018 |
| http://purl.uniprot.org/citations/10602018 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10602018 |
| http://purl.uniprot.org/citations/10602018 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10602018 |
| http://purl.uniprot.org/citations/10602018 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10602018 |