| http://purl.uniprot.org/citations/10604985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10604985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10604985 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. One SIRP of unknown function, designated SIRP beta 1, contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. Using a SIRP-specific mAb, we show that SIRP beta 1 is expressed in monocytes and dendritic cells and associates with the signal transduction molecule DAP12. SIRP beta 1/DAP12 complex formation was required for efficient cell-surface expression of SIRP beta 1. Stimulation of this complex induced tyrosine phosphorylation, mitogen-activated protein kinase activation, and cellular activation. Thus, SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.164.1.9"xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.164.1.9"xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Dietrich J."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Dietrich J."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Seiffert M."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Seiffert M."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Buehring H.-J."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/author | "Buehring H.-J."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/pages | "9-12"xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/pages | "9-12"xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/title | "Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/title | "Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells."xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/volume | "164"xsd:string |
| http://purl.uniprot.org/citations/10604985 | http://purl.uniprot.org/core/volume | "164"xsd:string |