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http://purl.uniprot.org/citations/10607560http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10607560http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10607560http://www.w3.org/2000/01/rdf-schema#comment"

Background

The Drosophila eye is composed of about 800 ommatidia, each of which becomes dorsoventrally polarised in a process requiring signalling through the Notch, JAK/STAT and Wingless pathways. These three pathways are thought to act by setting up a gradient of a signalling molecule (or molecules) often referred to as the 'second signal'. Thus far, no candidate for a second signal has been identified.

Results

The four-jointed locus encodes a type II transmembrane protein that is expressed in a dorsoventral gradient in the developing eye disc. We have analysed the function and regulation of four-jointed during eye patterning. Loss-of-function clones or ectopic expression of four-jointed resulted in strong non-autonomous defects in ommatidial polarity on the dorsoventral axis. Ectopic expression experiments indicated that localised four-jointed expression was required at the time during development when ommatidial polarity was being determined. In contrast, complete removal of four-jointed function resulted in only a mild ommatidial polarity defect. Finally, we found that four-jointed expression was regulated by the Notch, JAK/STAT and Wingless pathways, consistent with it mediating their effects on ommatidial polarity.

Conclusions

The clonal phenotypes, time of requirement and regulation of four-jointed are consistent with it acting in ommatidial polarity determination as a second signal downstream of Notch, JAK/STAT and Wingless. Interestingly, it appears to act redundantly with unknown factors in this process, providing an explanation for the previous failure to identify a second signal."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.org/dc/terms/identifier"doi:10.1016/s0960-9822(00)80081-0"xsd:string
http://purl.uniprot.org/citations/10607560http://purl.org/dc/terms/identifier"doi:10.1016/s0960-9822(00)80081-0"xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/author"Perrimon N."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/author"Perrimon N."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/author"Strutt D.I."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/author"Strutt D.I."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/author"Zeidler M.P."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/author"Zeidler M.P."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/name"Curr. Biol."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/name"Curr. Biol."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/pages"1363-1372"xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/pages"1363-1372"xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/title"The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/title"The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification."xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/10607560http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/10607560http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10607560
http://purl.uniprot.org/citations/10607560http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10607560
http://purl.uniprot.org/citations/10607560http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10607560
http://purl.uniprot.org/citations/10607560http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10607560
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