| http://purl.uniprot.org/citations/10611343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10611343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10611343 | http://www.w3.org/2000/01/rdf-schema#comment | "P75/AIRM1 is a recently identified surface molecule that belongs to the sialoadhesin family and displays homology with the myeloid cell antigen CD33. In lymphoid cells, p75/AIRM1 is confined to natural killer cells and mediates inhibition of their cytolytic activity. In this study, we show that p75/AIRM1 is also expressed by cells of the myelomonocytic cell lineage, in which it appears at a later stage as compared with CD33. In vitro proliferation and differentiation of cord blood-derived CD34(+) cells (induced by stem cell factor and granulocyte-macrophage colony-stimulating factor) were consistently inhibited by the addition of anti-p75/AIRM1 mAb. Engagement of CD33 led to inhibition in some experiments. A sharp decrease of cell proliferation/survival was detected in all three p75/AIRM1+ chronic myeloid leukemias analyzed when cultured in the presence of either anti-p75/AIRM1 or anti-CD33 mAbs. Thus, the present study suggests that p75/AIRM1 and CD33 may play a regulatory role in normal myelopoiesis and may be viewed as suitable target molecules to counteract the proliferation/survival of chronic myeloid leukemias."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.26.15091"xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.26.15091"xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Falco M."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Falco M."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Moretta L."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Moretta L."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Vitale M."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Vitale M."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Bacigalupo A."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Bacigalupo A."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Mingari M.C."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Mingari M.C."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Moretta A."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Moretta A."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Ponte M."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Ponte M."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Romagnani C."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Romagnani C."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Vitale C."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/author | "Vitale C."xsd:string |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10611343 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |