| http://purl.uniprot.org/citations/10615055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10615055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10615055 | http://www.w3.org/2000/01/rdf-schema#comment | "The Smad proteins mediate transforming growth factor-beta (TGFbeta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus. The Smad anchor for receptor activation (SARA) recruits Smad2 to the TGFbeta receptors for phosphorylation. The crystal structure of a Smad2 MH2 domain in complex with the Smad-binding domain (SBD) of SARA has been determined at 2.2 angstrom resolution. SARA SBD, in an extended conformation comprising a rigid coil, an alpha helix, and a beta strand, interacts with the beta sheet and the three-helix bundle of Smad2. Recognition between the SARA rigid coil and the Smad2 beta sheet is essential for specificity, whereas interactions between the SARA beta strand and the Smad2 three-helix bundle contribute significantly to binding affinity. Comparison of the structures between Smad2 and a comediator Smad suggests a model for how receptor-regulated Smads are recognized by the type I receptors."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.287.5450.92"xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.287.5450.92"xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Massague J."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Massague J."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Chen Y.-G."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Chen Y.-G."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Chong P.A."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Chong P.A."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Ozdamar B."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Ozdamar B."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Gyuricza C.A."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/author | "Gyuricza C.A."xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10615055 | http://purl.uniprot.org/core/name | "Science"xsd:string |