| http://purl.uniprot.org/citations/10617605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10617605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10617605 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(2+) induction of a subset of cellular and viral immediate-early activation genes in lymphocytes has been previously mapped to response elements recognized by the MEF2 family of transcription factors. Here, we demonstrate that Ca(2+) activation of MEF2 response elements in T lymphocytes is mediated in synergy by two Ca(2+)/calmodulin-dependent enzymes, the phosphatase calcineurin, and the kinase type IV/Gr (CaMKIV/Gr), which promote transcription by the MEF2 family members MEF2A and MEF2D. Calcineurin up-regulates the activity of both factors by an NFAT-dependent mechanism, while CaMKIV/Gr selectively and independently activates MEF2D. These results identify MEF2 proteins as effectors of a pathway of gene induction in T lymphocytes which integrates diverse Ca(2+) activation signals and may be broadly operative in several tissues."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.1.197"xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.1.197"xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/author | "Prywes R."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/author | "Prywes R."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/author | "Chatila T.A."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/author | "Chatila T.A."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/author | "Ho N."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/author | "Ho N."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/author | "Blaeser F."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/author | "Blaeser F."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/pages | "197-209"xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/pages | "197-209"xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/title | "Ca(2+)-dependent gene expression mediated by MEF2 transcription factors."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/title | "Ca(2+)-dependent gene expression mediated by MEF2 transcription factors."xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10617605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10617605 |
| http://purl.uniprot.org/citations/10617605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10617605 |