| http://purl.uniprot.org/citations/10618388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10618388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10618388 | http://www.w3.org/2000/01/rdf-schema#comment | "The recent availability of mice lacking the neuronal form of the vesicular monoamine transporter 2 (VMAT2) affords the opportunity to study its roles in storage and release. Carbon fiber microelectrodes were used to measure individual secretory events of histamine and 5-hydroxytryptamine (5-HT) from VMAT2-expressing mast cells as a model system for quantal release. VMAT2 is indispensable for monoamine storage because mast cells from homozygous (VMAT2(-/-)) mice, while undergoing granule-cell fusion, do not release monoamines. Cells from heterozygous animals (VMAT2(+/-)) secrete lower amounts of monoamine per granule than cells from wild-type controls. Investigation of corelease of histamine and 5-HT from granules in VMAT2(+/-) cells revealed 5-HT quantal size was reduced more than that of histamine. Thus, although vesicular transport is the limiting factor determining quantal size of 5-HT and histamine release, intragranular association with the heparin matrix also plays a significant role."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.97.1.162"xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.97.1.162"xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Wang Y.M."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Wang Y.M."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Wightman R.M."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Wightman R.M."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Michael D.J."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Michael D.J."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Travis E.R."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/author | "Travis E.R."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/pages | "162-167"xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/pages | "162-167"xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/title | "Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/title | "Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice."xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/10618388 | http://purl.uniprot.org/core/volume | "97"xsd:string |