| http://purl.uniprot.org/citations/10623794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10623794 | http://www.w3.org/2000/01/rdf-schema#comment | "Human heat shock protein 60 (hsp60) elicits a potent proinflammatory response in cells of the innate immune system and therefore has been proposed as a danger signal of stressed or damaged cells. We report here that macrophages of C3H/HeJ mice, carrying a mutant Toll-like-receptor (Tlr) 4 are nonresponsive to hsp60. Both the induction of TNF-alpha and NO formation were found dependent on a functional Tlr4 whereas stimulation of macrophages by CpG DNA was Tlr4 independent. We conclude that Tlr4 mediates hsp60 signaling. This is the first report of a putative endogenous ligand of the Tlr4 complex."xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.164.2.558"xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/author | "Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/author | "Kolb H."xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/author | "Burkart V."xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/author | "Flohe S."xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/pages | "558-561"xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/title | "Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex."xsd:string |
| http://purl.uniprot.org/citations/10623794 | http://purl.uniprot.org/core/volume | "164"xsd:string |
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