| http://purl.uniprot.org/citations/10625546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10625546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10625546 | http://www.w3.org/2000/01/rdf-schema#comment | "Caenorhabditis elegans dauer formation is controlled by multiple environmental factors. The chemosensory neuron ASI regulates dauer formation by secretion of DAF-7/TGF-beta, but the molecular targets of the DAF-7 ligand are incompletely defined and the cellular targets are unknown. We genetically characterized and cloned a putative transducer of DAF-7 signaling called daf-14 and found that it encodes a Smad protein. DAF-14 Smad has a highly unusual structure completely lacking the N-terminal domain found in all other Smad proteins known to date. daf-14 genetically interacts with daf-8, which encodes another Smad, and the interaction suggests partial functional redundancy between these two Smad proteins. We also studied the cellular targets of DAF-7 signaling by studying the sites of action of daf-14 and daf-4, the putative receptor for DAF-7. daf-14::gfp is expressed in multiple tissues that are remodeled during dauer formation. However, analysis of mosaics generated by free duplication loss and tissue-specific expression constructs indicate cell-nonautonomous function of daf-4, arguing against direct DAF-7 signaling to tissues throughout the animal. Instead, these experiments suggest the nervous system as a target of DAF-7 signaling and that the nervous system in turn regulates dauer formation by other tissues."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.1999.9545"xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.1999.9545"xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/author | "Thomas J.H."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/author | "Thomas J.H."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/pages | "192-204"xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/pages | "192-204"xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/title | "Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/title | "Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation."xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/volume | "217"xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://purl.uniprot.org/core/volume | "217"xsd:string |
| http://purl.uniprot.org/citations/10625546 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10625546 |
| http://purl.uniprot.org/citations/10625546 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10625546 |
| http://purl.uniprot.org/citations/10625546 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10625546 |
| http://purl.uniprot.org/citations/10625546 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10625546 |
| http://purl.uniprot.org/uniprot/Q21733 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10625546 |
| http://purl.uniprot.org/uniprot/F5GUE5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10625546 |