| http://purl.uniprot.org/citations/10629049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10629049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10629049 | http://www.w3.org/2000/01/rdf-schema#comment | "Host cell factor 1 (HCF-1) is a nuclear protein required for progression through G(1) phase of the cell cycle and, via its association with VP16, transcriptional activation of the herpes simplex virus immediate-early genes. Both functions require a six-bladed beta-propeller domain encoded by residues 1 to 380 of HCF-1 as well as an additional amino-terminal region. The beta-propeller domain is well conserved in HCF homologues, consistent with a critical cellular function. To date, the only known cellular target of the beta-propeller is a bZIP transcription factor known as LZIP or Luman. Whether the interaction between HCF-1 and LZIP is required for cell proliferation remains to be determined. In this study, we used directed mutations to show that all six blades of the HCF-1 beta-propeller contribute to VP16-induced complex assembly, association with LZIP, and cell cycle progression. Although LZIP and VP16 share a common tetrapeptide HCF-binding motif, our results reveal profound differences in their interaction with HCF-1. Importantly, with several of the mutants we observe a poor correlation between the ability to associate with LZIP and promote cell proliferation in the context of the full HCF-1 amino terminus, arguing that the HCF-1 beta-propeller domain must target other cellular transcription factors in order to contribute to G(1) progression."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.3.919-928.2000"xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.3.919-928.2000"xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/author | "Wilson A.C."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/author | "Wilson A.C."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/author | "Mahajan S.S."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/author | "Mahajan S.S."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/pages | "919-928"xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/pages | "919-928"xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/title | "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/title | "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP."xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10629049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10629049 |
| http://purl.uniprot.org/citations/10629049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10629049 |
| http://purl.uniprot.org/citations/10629049 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10629049 |
| http://purl.uniprot.org/citations/10629049 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10629049 |
| http://purl.uniprot.org/uniprot/P51610 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10629049 |
| http://purl.uniprot.org/uniprot/O43889 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10629049 |