| http://purl.uniprot.org/citations/10630383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10630383 | http://www.w3.org/2000/01/rdf-schema#comment | "Because the development of insulitis and diabetes is predictable in Lyp/Lyp congenic BB rats, we have characterized early islet inflammation in these rats to determine the cell subsets involved in the onset of autoimmune insulitis. Pancreas sections from prediabetic Lyp/Lyp, Lyp/+ and +/+ rats were analyzed by immunohistochemistry. We found W3/25+ cells in the exo- and endocrine tissue from all three genotypes, but intraislet insulitis was never found in Lyp/+ or +/+ rats. The onset of massive, intraislet B- and T-cell infiltration in Lyp/Lyp rats was preceded by Rel B+ cells in and around the islets, followed by ED1+ monocytes/macrophages. Rel B+ cells were more frequent in the parafollicular cortex of pancreatic lymph nodes from Lyp/Lyp than from Lyp/+ and +/+ rats. In the Lyp/Lyp thymus, we found significantly increased expression of IL-12p40 messenger RNA (mRNA; p<0.001), located in the Rel B-protein-rich corticomedullary junction. The NF-KB/Rel B complex specifically transactivates genes involved in antigen presentation in dendritic cells. Rel B+ cells in the islets may therefore mark the onset of autoimmune insulitis and antigen-specific activation of autoreactive T cells in the lymph nodes of diabetes prone Lyp/Lyp BB rats. In the thymus, Rel B+ cells may support the Lyp-dependent development of self-reactive thymocytes by activation of cytokine expression."xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.org/dc/terms/identifier | "doi:10.1097/00006676-200001000-00007"xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/author | "Lernmark A."xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/author | "Bieg S."xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/author | "Ellefsen K."xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/author | "Simonson W."xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/name | "Pancreas"xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/pages | "47-54"xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/title | "Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat."xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10630383 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10630383 |
| http://purl.uniprot.org/citations/10630383 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10630383 |
| http://purl.uniprot.org/uniprot/#_D3Z9V1-mappedCitation-10630383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10630383 |
| http://purl.uniprot.org/uniprot/#_D4A8H1-mappedCitation-10630383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10630383 |
| http://purl.uniprot.org/uniprot/D3Z9V1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10630383 |
| http://purl.uniprot.org/uniprot/D4A8H1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10630383 |